Surgical site infections are a significant complication that can prevent proper wound healing, require expensive treatment and may even lead to death in severe cases. Patients with higher body mass indices and with diabetes have an increased risk of developing incision infections.
Read MorePrevencio Inc. announced new data demonstrating its HART PAD test accurately diagnoses peripheral artery disease (PAD) in diabetes mellitus (DM) patients, a patient population in which PAD prevalence has traditionally been difficult to assess.
Read MoreMurine dermis contains functionally and spatially distinct fibroblast lineages that cease to proliferate in early postnatal life. Here, we propose a model in which a negative feedback loop between extracellular matrix (ECM) deposition and fibroblast proliferation determines dermal architecture.
Read MoreDiabetes is one of the leading causes of death in the United States. Type 2 diabetes is the most common form of diabetes, and it impacts the ability of the body to produce insulin, the hormone that regulates blood sugar levels. One serious complication of diabetes are ulcers that can form from wounds.
Read MoreThe innate immune response to lung infection takes priority at the expense of wound healing, according to a study published August 23 in the open-access journal PLOS Pathogens by a team of researcher at Brown University led by Amanda Jamieson.
Read MoreCold atmospheric plasmas (CAPs) are investigated for several medical applications; major research effort is devoted to the promotion of wound healing in of chronic wounds. These wounds, typically associated with diabetes, are a major health concern due to their high occurrence in the population, long healing time, and associated high costs. Cell culture studies and clinical trials show promising results towards wound reduction or closure using relatively short plasma treatment times between 45 s and 2 min.
Read MoreHard to heal wounds come in many different sizes, shapes, locations, and have many definitions of hard to heal based on underlying etiology of the wound, in practice it’s any wound that has not healed within a timely fashion, which is often due to lack of coordinated care with many patients receiving multiple courses of antibiotics and antimicrobial therapy.
Read MoreA randomised, controlled multicentre clinical trial was conducted at 14 wound care centres in the United States to confirm the efficacy of dehydrated human amnion/chorion membrane allograft (dHACM) for the treatment of chronic lower extremity ulcers in persons with diabetes. Patients with a lower extremity ulcer of at least 4 weeks duration were entered into a 2‐week study run‐in phase and treated with alginate wound dressings and appropriate offloading.
Read MoreFormation of new blood vessels, a process also known as angiogenesis, is one of the major clinical challenges in wound healing and tissue implants. To address this issue, researchers from Texas A&M University have developed a clay-based platform to deliver therapeutic proteins to the body to assist with the formation of blood vessels.
Read MoreImpaired wound healing and ulceration caused by diabetes mellitus, is a significant healthcare burden, markedly impairs quality of life for patients, and is the major cause of amputation worldwide. Current experimental approaches used to investigate the complex wound healing process often involve cultures of fibroblasts and/or keratinocytes in vitro, which can be limited in terms of complexity and capacity, or utilisation of rodent models in which the mechanisms of wound repair differ substantively from that in humans.
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